DBECats.com
Where science meets responsible breeding
Beyond the Blue Eyes
Dominant Blue Eyes in cats — commonly known as DBE — is not a single mutation. It is caused by multiple variants in the PAX3 gene. DBE cats may present with blue eyes, odd eyes, sectoral heterochromia or white markings ranging from minimal spotting to extensive depigmentation, but appearance alone cannot identify the underlying variant.
Current research has identified at least six genetic variants associated with dominant blue eyes in cats, each with its own genomic location, molecular mechanism and potential health implications. Understanding which variant is present is essential for accurate interpretation of research, health considerations and responsible breeding decisions.
PAX3-associated white markings, variable eye colour and differences in hearing outcomes across variants mean that treating all DBE cats as a single group oversimplifies a far more complex genetic landscape.
About DBECats.com
DBECats.com is an independent educational platform dedicated to the genetics of Dominant Blue Eyes (DBE) in cats.
The platform was established to provide an evidence-based resource focused on the rapidly evolving science of feline DBE genetics.
Rather than treating all DBE cats as genetically identical, DBECats.com reflects the growing body of research demonstrating that Dominant Blue Eyes comprises multiple genetically distinct variants, each of which should be evaluated according to its own biological mechanism and the available scientific evidence.
By presenting current research in a clear, balanced and accessible way, DBECats.com aims to support accurate interpretation, responsible breeding practices and informed discussion within the international cat community.
Our mission is simple: to promote scientific accuracy, encourage critical thinking and make reliable, evidence-based information accessible to breeders, judges, veterinarians and cat owners worldwide.
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Questions, suggestions or feedback?
If you would like to discuss DBE genetics, contribute scientific information or report an error, please get in touch.
We aim to respond to all enquiries as soon as possible.